Axen™ Comprehensive Cancer Panels are based on capture hybridization method, providing comprehensive coverage cancer related genes. It is designed to detect clinically actionable genetic alterations in patients with solid tumor and to provide reliable results with evidence of resistance.

Cancers are divided into detailed items according to the gene mutations, which contributes to improved response (about 75% of patients exhibit different effects when the same anti-cancer drug is prescribed) and provides personalized treatment for cancer patients while minimizing adverse effects.

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We perform cancer discovery with three panels.

Axen Cancer Panel 1_88 genes

we check SNV / InDel variants of 88 genes (are listed) and three fusion genes (ALK, ROS1, RET).

ABL1, AKT1, AKT3, ALK, APC, AR, ATM, AXL, BRAF, BRCA1, BRCA2, CCND1, CDH1, CDK4, CDK6, CDKN2A, CEBPA, CSF1R, CTNNB1, DDR2, EGFR, ERBB2, ERBB3, ERBB4, ERG, ESR1, ETV1, ETV4, ETV5, EZH2, FANCA, FANCC, FANCF, FANCG, FBXW7, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, FOXL2, GNA11, GNAQ, GNAS, HNF1A, HRAS, IDH1, IDH2, JAK1, JAK2, JAK3, KDR, KIT, KRAS, MAP2K1, MAP2K2, MAP2K4, MET, MLH1, MPL, MTOR, MYC, MYCN, NOTCH1, NPM1, NRAS, NTRK1, NTRK2, NTRK3, PDGFRA, PIK3CA, PIK3R1, PPARG, PTEN, PTPN11, RAF1, RB1, RET, ROS1, RUNX1, SMAD4, SMARCB1, SMO, SRC, STK11, TP53, VHL, WT1

Axen Cancer Panel 2_171 genes

we check SNV / InDel variants of 170 genes, 25 fusion genes (are listed) and a promoter abnormality (TERT).

SNV / InDel (170 genes):

ABL1, ABL2, AKT1, AKT2, AKT3, ALK, APC, AR, ARAF, ASXL1, ATM, ATR, AURKA, AURKB, AURKC, AXL, BAP1, BCL2, BRAF, BRCA1, BRCA2, BRD2, BRD3, BRD4, CBFB, CCND1, CCND2, CCND3, CCNE1, CDH1, CDK12, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CEBPA, CHEK2, CREBBP, CRKL, CSF1R, CTNNB1, DDR1, DDR2, DNMT3A, DOT1L, EGFR, EPHA3, ERBB2, ERBB3, ERBB4, ERCC2, ERG, ERRFI1, ESR1, ETV1, ETV4, ETV5, ETV6, EWSR1, EZH2, FBXW7, FGFR1, FGFR2, FGFR3, FGFR4, FLCN, FLT1, FLT3, FLT4, FOXL2, GNA11, GNAQ, GNAS, HDAC9, HGF, HRAS, IDH1, IDH2, IGF1R, IGF2, JAK1, JAK2, JAK3, KDR, KIT, KMT2A, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAP3K4, MAPK1, MAPK3, MAPK8, MCL1, MDM2, MDM4, MED12, MEN1, MET, MITF, MLH1, MPL, MSH2, MSH6, MTOR, MYC, MYCN, MYD88, NF1, NF2, NFKBIA, NKX2-1, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NPM1, NRAS, NTRK1, NTRK2, NTRK3, NUTM1, PDGFB, PDGFRA, PDGFRB, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PIK3R2, POLE, PPARG, PTCH1, PTEN, RAB35, RAD50, RAF1, RARA, RB1, RET, RHEB, RICTOR, RNF43, ROS1, RSPO1, RSPO2, RUNX1, SMAD2, SMAD4, SMARCA4, SMARCB1, SMO, SRC, STK11, SYK, TET2, TMPRSS2, TOP2A, TP53, TSC1, TSC2, VHL, WT1, XPO1, ZNRF3

Fusion (25 genes)

ABL1, AKT3, ALK, BCL2, BRAF, EGFR, ERG, ETV1, EWSR1, FGFR1, FGFR2, FGFR3, JAK2, KMT2A, MYC, NPM1, NTRK1, PDGFRA, PDGFRB, PPARG, RAF1, RARA, RET, ROS1,TMPRSS2

Axen Cancer Master Panel_546 genes

we check SNV / InDel variants of 546 genes, 48 fusion genes (are listed) and a promoter abnormality (TERT).

SNV / InDel (546 genes):

ABL1, ABL2, ABRAXAS1, ACVR1, ACVR1B, ADGRA2, AGO2, AHNAK2, AKT1, AKT2, AKT3, ALK, ALOX12B, AMER1, ANKRD11, APC, AR, ARAF, ARFRP1, ARID1A, ARID1B, ARID2, ARID5B, ASXL1, ASXL2, ATM, ATR, ATRX, AURKA, AURKB, AURKC, AXIN1, AXIN2, AXL, B2M, BABAM1, BAP1, BARD1, BBC3, BCL10, BCL2, BCL2L1, BCL2L11, BCL2L2, BCL6, BCOR, BCORL1, BCR, BIRC3, BLM, BMPR1A, BRAF, BRCA1, BRCA2, BRD2, BRD3, BRD4, BRIP1, BTG1, BTK, CALR, CARD11, CARM1, CASP8, CBFB, CBL, CCND1, CCND2, CCND3, CCNE1, CCNQ, CD274, CD276, CD79A, CD79B, CDC42, CDC73, CDH1, CDK12, CDK4, CDK6, CDK8, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CEBPA, CENPA, CHD2, CHD4, CHEK1, CHEK2, CIC, COP1, CREBBP, CRKL, CRLF2, CSDE1, CSF1R, CSF3R, CTCF, CTLA4, CTNNA1, CTNNB1, CUL3, CXCR4, CYLD, CYSLTR2, DAXX, DCUN1D1, DDR1, DDR2, DICER1, DIS3, DNAJB1, DNMT1, DNMT3A, DNMT3B, DOT1L, DROSHA, DUSP4, E2F3, EED, EGFL7, EGFR, EIF1AX, EIF4A2, EIF4E, ELF3, ELOC, EMSY, EP300, EPAS1, EPCAM, EPHA3, EPHA5, EPHA7, EPHB1, ERBB2, ERBB3, ERBB4, ERCC2, ERCC3, ERCC4, ERCC5, ERF, ERG, ERRFI1, ESR1,ETV1, ETV4, ETV5, ETV6, EWSR1, EZH1, EZH2, FAM46C, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCL, FAS, FAT1, FBXW7, FGF10, FGF14, FGF19, FGF23, FGF3, FGF4, FGF6, FGFR1, FGFR2, FGFR3, FGFR4, FH, FLCN, FLT1, FLT3, FLT4, FOXA1, FOXL2, FOXO1, FOXP1, FRS2, FUBP1, FYN, GABRA6, GATA1, GATA2, GATA3, GATA4, GATA6, GID4, GLI1, GNA11, GNA13, GNAQ, GNAS, GPS2, GREM1, GRIN2A, GRM3, GSK3B, H3F3A, H3F3B, H3F3C, HDAC9, HGF, HIST1H1C, HIST1H2BD, HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J, HIST2H3A, HIST2H3C, HIST2H3D, HIST3H3, HLA-A, HLAB, HNF1A, HOXB13, HRAS, HSD3B1, HSP90AA1, ICOSLG, ID3, IDH1, IDH2, IFNGR1, IGF1, IGF1R, IGF2, IKBKE, IKZF1, IL10, IL7R, INHA, INHBA, INPP4A, INPP4B, INPPL1, INSR, IRF2, IRF4, IRS1, IRS2, JAK1, JAK2, JAK3, JUN, KAT6A, KDM5A, KDM5C, KDM6A, KDR, KEAP1, KEL, KIT, KLF4, KLHL6, KMT2A, KMT2B, KMT2C, KMT2D, KMT5A, KNSTRN, KRAS, LATS1, LATS2, LMO1, LRP1B, LYN, LZTR1, MAGI2, MALT1, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAP3K13, MAP3K14, MAP3K4, MAPK1, MAPK3, MAPK8, MAPKAP1, MAX, MCL1, MDC1, MDM2, MDM4, MED12, MEF2B, MEN1, MET, MGA, MITF, MLH1, MPL, MRE11, MSH2, MSH3, MSH6, MSI1, MSI2, MST1, MST1R, MTOR, MUTYH, MYB, MYC, MYCL, MYCN, MYD88, MYOD1, NBN, NCOA3, NCOR1, NEGR1, NF1, NF2, NFE2L2, NFKBIA, NKX2-1, NKX3-1, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NPM1, NRAS,NSD1, NSD2, NSD3, NTHL1, NTRK1, NTRK2,NTRK3, NUF2, NUP93, NUTM1, PACRG, PAK1, PAK3, PAK5, PAK6, PALB2, PARP1, PAX5, PAX8, PBRM1, PDCD1, PDCD1LG2, PDGFB, PDGFRA, PDGFRB, PDK1, PDPK1, PGR, PHOX2B, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIM1, PLCG2, PLK2, PMAIP1, PMS1, PMS2, PNRC1, POLD1, POLE, PPARG, PPM1D, PPP2R1A, PPP4R2, PPP6C, PRDM1, PRDM14, PREX2, PRKAR1A, PRKCI, PRKD1, PRKDC, PRSS1, PRSS8, PTCH1, PTEN, PTP4A1, PTPN11, PTPRD, PTPRS, PTPRT, QKI, RAB35, RAC1, RAC2, RAD21, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RAD52, RAD54L, RAF1, RANBP2, RARA, RASA1, RB1, RBM10, RECQL, RECQL4, REL, RET, RHEB, RHOA, RICTOR, RIT1, RNF43, ROS1, RPS6KA4, RPS6KB2, RPTOR, RRAGC, RRAS, RRAS2, RSPO1, RSPO2, RTEL1, RUNX1, RUNX1T1, RXRA, RYBP, SDHA, SDHAF2, SDHB, SDHC, SDHD, SESN1, SESN2, SESN3, SETD2, SF3B1, SH2B3, SH2D1A, SHOC2, SHQ1, SLIT2, SLX4, SMAD2, SMAD3, SMAD4, SMARCA4, SMARCB1, SMARCD1, SMO, SMYD3, SNCAIP, SOCS1, SOS1, SOX10, SOX17, SOX2, SOX9, SPEN, SPOP, SPRED1, SPTA1, SRC, SRSF2, STAG2, STAT3, STAT4, STAT5A, STAT5B, STK11, STK19, STK40, SUFU, SUZ12, SYK, TAF1, TAP1, TAP2, TBX3, TCF3, TCF7L2, TEK, TERT, TET1, TET2, TGFBR1, TGFBR2, TMEM127, TMPRSS2, TNFAIP3, TNFRSF14, TOP1, TOP2A, TP53, TP53BP1, TP63, TRAF2, TRAF7, TSC1, TSC2, TSHR, U2AF1, UPF1, VEGFA, VHL, VTCN1, WISP3, WT1, WWTR1, XIAP, XPO1, XRCC2, YAP1, YES1, ZBTB2, ZFHX3, ZNF217, ZNF703, ZNRF3, ZRSR2

Fusion (48 genes)

ABL1, AKT3, ALK, AXL, BCL2, BCL6, BRAF, CCND1, CIITA, CREB3L2, EGFR, EML4, ERG, ETV1, ETV6, EWSR1, FGFR1, FGFR2, FGFR3, FUS, HIC1, JAK2, KMT2A, KRAS, MAGI3, MBIP, MET, MYC, NPM1,NRG1, NTRK1, NTRK2, NTRK3, PAX5, PAX8, PDGFRA, PDGFRB, PPARG, RAF1, RARA, RET, ROS1, SLC45A3, SS18, TMPRSS2, TRA, TRB, TRG

Advantages

  • Three different panels are available with 88 genes, 171 genes and 546 genes
  • 2,000x of deep coverage SNP, InDel, CNV and Fusion Genes
  • Immunotherapy is available by microsatellite instability (MSI) and tumor mutational burden (TMB)

Sample

Peripheral blood, FFPE, DNA

Turnaround Time

2-4 weeks from sample’s arrival at Macrogen’s clinical lab.

Test procedure